HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-Methoxy-7-chloro-5-phenyl-3H-1,5-benzodiazepin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 8-chloro-4-(nitrosomethylamino)-1-phenyl-3H-1,5-benzodiazepin-2-one | HCID 178526374 | — |
| Product | 2-Methoxy-7-chloro-5-phenyl-3H-1,5-benzodiazepin-4-one | HCID 20329316 | — |
Reaction Steps
A mixture of 3.3g (0.01M) of 7-chloro-3,5-dihydro-2-(N-nitrosomethylamino)-5-phenyl-4H-1,5-benzodiazepin-4-one, 5 ml of triethylamine and 50 ml. of methanol was heated to reflux for 2 hrs. The solvents were evaporated under reduced pressure and the residue was crystallized from ether/hexane to yield the above named product, m.p. 136°-138°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04111934 |
| Source dataset | uspto-grants-1978_09 |
| ORD ID | ord-0764c9a458584342b755edae400cafcd |
| Source note | uspto-grants-1978_09 |