Ethylene → Valine methyl ester

Participants

Reaction Steps

7.7 g (8.5 mmols) of lithium cobalt-phthalocyanine in 50 ml of methanol are stirred with 846 mg (3.0 mmols) of 2-bromoethoxycarbonyl-L-valine methyl ester for 2 hours at 20° C (end of the evolution of ethylene) and the mixture is worked up as described in Example 56. 300 mg (76%) of L-valine methyl ester are obtained. Boiling point10 = 53° C. [α]D25 = +42.2° (c = 0.7 in ethanol).

Provenance & Evidence