Dimethyl Sulfate → HCID 86735986, compound

HRID 1763290Notes

Reaction equation

HRID 1763290 reaction equation
[NH2:1][C:2]1[C:3]([I:25])=[C:4]([C:8]([I:24])=[C:9]([NH:12][C:13](=[O:23])[CH2:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH3:22])[C:10]=1[I:11])[C:5]([OH:7])=[O:6].S(OC)(O[CH3:30])(=O)=O>>[NH2:1][C:2]1[C:3]([I:25])=[C:4]([C:8]([I:24])=[C:9]([N:12]([CH3:30])[C:13](=[O:23])[CH2:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH3:22])[C:10]=1[I:11])[C:5]([OH:7])=[O:6]

Participants

3

Reactant 2

HCID 6497Dimethyl SulfateHCID 86735987HCID 86735987, compound

Product 1

HCID 86735986HCID 86735986, compound

Procedure

3-Amino-2,4,6-triiodo-5-(N-methyl-3,6,9-trioxadecanamido)benzoic Acid [C; Ro is H(CH2OCH2)3CON(CH3), Q is H, Z is OH] was prepared by methylation of 3-amino-2,4,6-triiodo-5-(3,6,9-trioxadecanamido)benzoic acid with dimethyl sulfate according to the procedure of Example 41, and was obtained as an amorphous pink solid, m.p. 100°-109° C. when recrystallized from methanol.

Workup

  1. customwas obtained as an amorphous pink solid, m.p. 100°-109° C. when
  2. customrecrystallized from methanol

Sources & evidence

ORD record
ord-ad87fc8d919343b59f9b1003260e728a
Source dataset
uspto-grants-1978_09
Patent number
US04111937

Reaction notes

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