Methanesulfonyl chloride → HCID 54301768, compound

HRID 1763293Notes

Reaction equation

HRID 1763293 reaction equation
[NH2:1][C:2]1[C:7]2[C:8]3[CH:9]=[N:10][CH:11]=[CH:12][C:13]=3[C:14]([CH3:17])([CH3:16])[O:15][C:6]=2[CH:5]=[C:4]([CH:18]([CH2:20][CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=2)[CH3:19])[CH:3]=1.[CH3:30][S:31](Cl)(=[O:33])=[O:32]>>[F:29][C:26]1[CH:25]=[CH:24][C:23]([CH2:22][CH2:21][CH2:20][CH:18]([C:4]2[CH:3]=[C:2]([NH:1][S:31]([CH3:30])(=[O:33])=[O:32])[C:7]3[C:8]4[CH:9]=[N:10][CH:11]=[CH:12][C:13]=4[C:14]([CH3:17])([CH3:16])[O:15][C:6]=3[CH:5]=2)[CH3:19])=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 20309733HCID 20309733, compound

Product 1

HCID 54301768HCID 54301768, compound

Procedure

The titled compound was prepared by reacting 10-amino-8-[5-(4-fluorophenyl)-2-pentyl]-5,5-dimethyl-5H-[1]benzopyrano[4,3-c]pyridine with methanesulfonyl chloride according to the method of Example 3. The crude product was filtered and recrystallized from acetonitrile; m.p. 208°-209°.

Workup

  1. filtrationThe crude product was filtered
  2. customrecrystallized from acetonitrile

Sources & evidence

ORD record
ord-2ceb1b6af7e74e12ae8030f4adadc197
Source dataset
uspto-grants-1978_09
Patent number
US04111942

Reaction notes

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