Dicyclohexylcarbodiimide → 5,5-Dimethyl-8-(1,2-dimethylheptyl)-10-(4-piperidinobutyrylamino)-5H-[1]benzopyrano [4,3-c]pyridine hydrochloride

Participants

Reaction Steps

A mixture of 0.87 g. (2.47 mmole) of 10-amino-5,5-dimethyl-8-(1,2-dimethylheptyl)-5H-[1]benzopyrano[4,3-c]-pyridine, 0.51 g. (2.47 mmole) of 4-piperidinobutyric acid hydrochloride, 0.56 g. (2.72 mmole) of dicyclohexylcarbodiimide, and 50 ml. of dry methylene chloride was stirred at room temperature for 72 hours. The mixture was cooled and filtered and the filtrate concentrated to a residue which was recrystallized from methylene chloride-ether, m.p. 185-186°.

Provenance & Evidence