Ammonium Chloride → HCID 20309577, compound

HRID 1763311Notes

Reaction equation

HRID 1763311 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][C:4]=1[Li].[CH3:14][N:15]1[C:19](=[O:20])[CH2:18][CH2:17][C:16]1=[O:21].[Cl-].[NH4+]>CCOCC.C1C=CC=CC=1>[CH3:14][NH:15][C:16](=[O:21])[CH2:17][CH2:18][C:19](=[O:20])[C:4]1[CH:5]=[C:6]([C:9]([F:12])([F:11])[F:10])[CH:7]=[CH:8][C:3]=1[O:2][CH3:1]

Participants

6

Reactant 3

HCID 25517Ammonium ChlorideHCID 707172,5-Pyrrolidinedione, 1-methyl-HCID 178506727HCID 178506727, compound

Product 1

HCID 20309577HCID 20309577, compound

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 3283Diethyl EtherSolvent

Procedure

A solution of 2-methoxy-5-trifluoromethylphenyllithium in ether was added to a cold stirred solution of N-methylsuccinimide in benzene. The resultant mixture was allowed to stand overnight and was then decomposed with ammonium chloride solution to give N-methyl 3-(2-methoxy-5-trifluoromethylbenzoyl)propionamide.

Sources & evidence

ORD record
ord-4155b004a68b41adb1eb9d2786750bb6
Source dataset
uspto-grants-1978_09
Patent number
US04111936

Reaction notes

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