Epibromohydrin → HCID 20309567, compound

Participants

Reaction Steps

Methyl 3-(5-acetamido-2-hydroxybenzoyl)propionate (0.75 g, 0.0028 mole) anhydrous potassium carbonate (0.39 g, 0.0028 mole), epibromohydrin (0.78 g, 0.00565 mole) and dry ethyl methyl ketone (20 ml) were stirred and heated under reflux for 16 hours. The cooled mixture was filtered and evaporated under reduced pressure to an oil which was purified by elution from a silica column with chloroform-methanol to give methyl 3-[5-acetamido-2-(2,3-epoxypropoxy)-benzoyl]propionate (0.52 g, 57%, m.p. 84°-87°). (Found: M+, 321, C16H19NO6 requires M, 321).

Provenance & Evidence