Sodium Hydroxide → HCID 20309559, compound

HRID 1763325Notes

Reaction equation

HRID 1763325 reaction equation
[C:1]([NH:5][CH2:6][CH:7]([OH:28])[CH2:8][O:9][C:10]1[CH:19]=[CH:18][C:13]([C:14]([O:16]C)=[O:15])=[CH:12][C:11]=1[C:20](=[O:27])[CH2:21][CH2:22][C:23]([O:25]C)=[O:24])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>C(O)(=O)C>[C:1]([NH:5][CH2:6][CH:7]([OH:28])[CH2:8][O:9][C:10]1[CH:19]=[CH:18][C:13]([C:14]([OH:16])=[O:15])=[CH:12][C:11]=1[C:20](=[O:27])[CH2:21][CH2:22][C:23]([OH:25])=[O:24])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20309576HCID 20309576, compound

Product 1

HCID 20309559HCID 20309559, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Methyl 4-(3-t-butylamino-2-hydroxypropoxy)-3-(3-carbomethoxypropionyl)benzoate was heated with dilute sodium hydroxide solution until hydrolysis was complete. The solution was neutralised with acetic acid then evaporated under reduced pressure. Extraction of the residue with ethanol and evaporation of the extracts gave 4-(3-t-butylamino-2-hydroxypropoxy)-3-(3-carboxypropionyl)benzoic acid.

Workup

  1. customthen evaporated under reduced pressure
  2. extractionExtraction of the residue
  3. customwith ethanol and evaporation of the extracts

Sources & evidence

ORD record
ord-c54c7a0838de40728c111b1e3410eb8c
Source dataset
uspto-grants-1978_09
Patent number
US04111936

Reaction notes

Loading…