Epibromohydrin → HCID 20309565, compound

HRID 1763335Notes

Reaction equation

HRID 1763335 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:16])=[C:6]([CH:15]=1)[C:7]([CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[O:8].[CH2:17]([CH:19]1[O:21][CH2:20]1)Br>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:16][CH2:17][CH:19]2[O:21][CH2:20]2)=[C:6]([CH:15]=1)[C:7]([CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[O:8]

Participants

3

Reactant 2

HCID 18430EpibromohydrinHCID 14452847HCID 14452847, compound

Product 1

HCID 20309565HCID 20309565, compoundYield 53%

Procedure

Methyl 3-(5-chloro-2-hydroxybenzoyl)propionate was reacted with epibromohydrin in a similar manner to the procedure described in Example 1 (ii) to give methyl 3-[5-chloro-2-(2,3-epoxypropoxy)benzoyl]propionate as an oil (53%).

Sources & evidence

ORD record
ord-6445772d3c6044af9e26062f6cb6a5ad
Source dataset
uspto-grants-1978_09
Patent number
US04111936

Reaction notes

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