HCID 20309894, compound → 2-AMINO-3-CYANO-5-NITROTHIOPHENE

HRID 1763367Notes

Reaction equation

HRID 1763367 reaction equation
C([NH:3][C:4]1[S:5][C:6]([N+:12]([O-:14])=[O:13])=[CH:7][C:8]=1[C:9](=O)[NH2:10])=O.C(NC1SC([N+]([O-])=O)=CC=1C(=O)N)(=O)C1C=CC=CC=1>>[NH2:3][C:4]1[S:5][C:6]([N+:12]([O-:14])=[O:13])=[CH:7][C:8]=1[C:9]#[N:10]

Participants

3

Reactant 2

HCID 20309894HCID 20309894, compoundHCID 20309899HCID 20309899, compound

Product 1

HCID 110520602-AMINO-3-CYANO-5-NITROTHIOPHENEYield 60%

Procedure

In place of the 83.9 parts of 2-formylamino-3-carbamoyl-5-nitrothiophene used in Example 1 there are used 113.6 parts of 2-benzoylamino-3-carbamoyl-5-nitrothiophene, the first stage of the reaction being carried out for 15 minutes at 60° C. (instead of at 70°-75° C. as in Example 1). 2-Amino-3-cyano-5-nitrothiophene is obtained in an overall yield of 60%.

Workup

  1. custominstead of at 70°-75° C.

Sources & evidence

ORD record
ord-ee346fbc37de48f88dc6746961bf2509
Source dataset
uspto-grants-1978_09
Patent number
US04111956

Reaction notes

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