HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(1-Pyrrolidinyl)-4-phenoxy-4-sulphamylbenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Piretanide | HCID 4849 | — |
| Reactant | 3-(1-Pyrrolidinyl)-4-phenoxy-5-aminobenzoic acid | HCID 21312072 | — |
| Reactant | 3-(1-Pyrrolidinyl)-4-phenoxy-5-chlorosulphonyl-benzoic acid | HCID 21312108 | — |
| Product | 3-(1-Pyrrolidinyl)-4-phenoxy-4-sulphamylbenzoic acid | HCID 70606662 | — |
Reaction Steps
The hydrochloride of the 3-(1-pyrrolidinyl)-4-phenoxy-5-aminobenzoic acid is converted in the manner described in Example 35 over the 3-(1-pyrrolidinyl)-4-phenoxy-5-chlorosulphonyl-benzoic acid into the desired 3-(1-pyrrolidinyl)-4-phenoxy-5-sulphamylbenzoic acid melting at 225°-226° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04111953 |
| Source dataset | uspto-grants-1978_09 |
| ORD ID | ord-c4844921fbf343c2b4510ca7e2936807 |
| Source note | uspto-grants-1978_09 |