Sulfuric Acid → HCID 53792494, compound

HRID 1763389Notes

Reaction equation

HRID 1763389 reaction equation
[C:1]12(O)[CH2:10][CH:6]([CH2:7][CH2:8][CH2:9]1)[CH:5]1[CH2:11][CH:2]2[CH2:3][CH2:4]1.S(=O)(=O)(O)[OH:14].[C:18](#[N:20])[CH3:19]>>[C:18]([NH:20][C:1]12[CH2:10][CH:6]([CH2:7][CH2:8][CH2:9]1)[CH:5]1[CH2:11][CH:2]2[CH2:3][CH2:4]1)(=[O:14])[CH3:19]

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 6342AcetonitrileHCID 13070378HCID 13070378, compound

Product 1

HCID 53792494HCID 53792494, compoundYield 92%

Procedure

1.18 Grams (5.1 millimoles) of 1-bromotricyclo [4.3.1.12,5 ] undecane (X=Br in formula (II)) are dissolved in 10 ml of acetonitrile. The solution is cooled and kept at 0° C, and then 2.5 ml of concentrated sulfuric acid are added dropwise under stirring over 30 minutes. The stirring is continued further at room temperature for 20 hours. The reaction mixture is treated in the same manner as described in Example 1 to obtain 0.98 g (yield 92%) of 1-acetylaminotricyclo [4.3.1.12,5 ] undecane.

Workup

  1. temperatureThe solution is cooled
  2. customkept at 0° C
  3. waitThe stirring is continued further at room temperature for 20 hours
  4. additionThe reaction mixture is treated in the same manner

Sources & evidence

ORD record
ord-ca312fe3df6c4629a15a8cd7c7a1d000
Source dataset
uspto-grants-1978_09
Patent number
US04111990

Reaction notes

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