Carbon Dioxide → HCID 86735988, compound

HRID 1763392Notes

Reaction equation

HRID 1763392 reaction equation
[CH3:1][C:2]1([CH3:9])[CH:7]([OH:8])[C:5](=[O:6])[O:4][CH2:3]1.C(=O)([O-])[O-:11].[Li+:14].[Li+].C(=O)=O>O>[OH2:4].[C:5]([O-:11])(=[O:6])[C@@H:7]([C:2]([CH2:3][OH:4])([CH3:9])[CH3:1])[OH:8].[Li+:14]

Participants

5

Reactant 3

HCID 280Carbon DioxideHCID 989(+-)-PantolactoneHCID 11125Lithium Carbonate

Product 1

HCID 86735988HCID 86735988, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A slurry of 1.00 kilogram of racemic DL-pantolactone and 300 grams of lithium carbonate in 1.5 liters of water was continuously stirred and heated at boiling temperature in a flask provided with a stirrer and reflux condenser for 1.5 hours. After all the evolved carbon dioxide had been expelled, the reaction mixture was filtered while hot and 25 grams of lithium carbonate was thus recovered therefrom. When the filtrate was cooled and stirred, 700 grams of crystals of racemic DL-lithium pantoate monohydrate having a melting point of 107°-110° C, amounting to 53.0% of the theoretical yield, separated and was collected. By evaporation of the mother liquor a further amount of DL-lithium pantoate, equivalent to 42% of the original DL-pantolactone, was recovered.

Workup

  1. temperatureheated
  2. customprovided with a stirrer
  3. temperaturereflux condenser for 1.5 hours
  4. filtrationthe reaction mixture was filtered while hot and 25 grams of lithium carbonate
  5. customwas thus recovered
  6. temperatureWhen the filtrate was cooled
  7. custom700 grams of crystals of racemic DL-lithium pantoate monohydrate having a melting point of 107°-110° C, amounting to 53.0% of the theoretical yield, separated
  8. customwas collected
  9. customBy evaporation of the mother liquor a further amount of DL-lithium pantoate
  10. customequivalent to 42% of the original DL-pantolactone, was recovered

Sources & evidence

ORD record
ord-5125f1c316bb402f907ae436584daa52
Source dataset
uspto-grants-1978_09
Patent number
US04111987

Reaction notes

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