Formic Acid → Formate

Participants

Reaction Conditions

Reaction Steps

38 kg of a mixture of 60% (R) allethrolone and 40% of (S) allethrolone resulting from the industrial resolution of racemic allethrolone and having a specific rotation [α]D20 = -7.5° C (c = 10% in chloroform) and the proportion of which is shown by its circular dichroism, were added to 190 liters of formic acid and the mixture refluxed with stirring under nitrogen at a temperature of about 102° C for 26 hours. The mixture was cooled and residual formic acid was distilled under reduced pressure to obtain raw formate of racemic (R,S) allethrolone which was used as is for the next step.

Provenance & Evidence