反应详情

温度

160 °C

Five g. of o-benzoyl-β-phenylpropionic acid, 13 g. of anhydrous aluminum chloride and 1.3 g. of sodium chloride are admixed together and heated at 160° C for 1 hour. After cooling, water is added to the mixture, followed by extraction with chloroform. The extract is washed with a 5% aqueous solution of sodium bicarbonate and water in that order and, then, dried. The solvent is distilled off under reduced pressure and the residue is dissolved in ethanol. The solution is decolorized with activated carbon and recrystallized from ethanol. The procedure yields 4-benzoylindan-1-one as crystals melting at 86°-88° C.

1. temperatureAfter cooling
2. extractionfollowed by extraction with chloroform
3. washThe extract is washed with a 5% aqueous solution of sodium bicarbonate and water in that order
4. customdried
5. distillationThe solvent is distilled off under reduced pressure
6. dissolutionthe residue is dissolved in ethanol
7. customrecrystallized from ethanol