反应详情

In 6 ml. of chloroform is dissolved 5.7 g. of methyl 1-hydroxyindan-4-carboxylate and, under cooling with ice, the solution is stirred. Then, 3 ml. of thionyl chloride is added dropwise and, after the dropwise addition has been completed, the mixture is further stirred under cooling with ice for one hour. Then, the solvent and the excess thionyl chloride are distilled off under reduced pressure. The residue obtained is purified by column chromatography on silica gel (500 g. silica gel; eluant: chloroform). The procedure gives methyl 1-chloroindan-4-carboxylate as an oily product.

1. additionafter the dropwise addition
2. stirringthe mixture is further stirred
3. temperatureunder cooling with ice for one hour
4. distillationThen, the solvent and the excess thionyl chloride are distilled off under reduced pressure
5. customThe residue obtained
6. customis purified by column chromatography on silica gel (500 g. silica gel; eluant: chloroform)