HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorothiazole → 1-[(Naphthalen-2-yl)methyl]-4-(1,3-thiazol-2-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorothiazole | HCID 76429 | — |
| Reactant | 1-(Naphthalen-2-ylmethyl)piperazine | HCID 910537 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-[(Naphthalen-2-yl)methyl]-4-(1,3-thiazol-2-yl)piperazine | HCID 20310342 | 54.9% |
Reaction Steps
In a manner similar to that described above, but starting from 45.2 g (0.2 mole) of 1-(2-naphthylmethyl)-piperazine and 12 g (0.1 mole) of 2-chlorothiazole in 150 ml of dimethylformamide at 150° C., there were obtained 17 g of 1-(2-naphthylmethyl)-4-(2-thiazolyl)-piperazine as beige crystals melting at 83°-84° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04112092 |
| Source dataset | uspto-grants-1978_09 |
| ORD ID | ord-3efcaee71f41492089ca12dedd5cc4cf |
| Source note | uspto-grants-1978_09 |