Sodium Methoxide → HCID 178476914, compound

HRID 1763468Notes

Reaction equation

HRID 1763468 reaction equation
[C:1]([NH:11][C@@H:12]1[C:38](=[O:39])[N:14]2[C:15]([C:35]([OH:37])=[O:36])=[C:16]([CH:19]([S:29][C:30]3[NH:34][N:33]=[N:32][N:31]=3)[CH2:20][P:21]([O:26][CH2:27][CH3:28])([O:23][CH2:24][CH3:25])=[O:22])[CH2:17][S:18][C@H:13]12)(=[O:10])[C@@H:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[OH:3].C[O-].[Na+:42]>CO>[Na+:42].[C:1]([NH:11][C@@H:12]1[C:38](=[O:39])[N:14]2[C:15]([C:35]([O-:37])=[O:36])=[C:16]([CH:19]([S:29][C:30]3[NH:34][N:33]=[N:32][N:31]=3)[CH2:20][P:21]([O:26][CH2:27][CH3:28])([O:23][CH2:24][CH3:25])=[O:22])[CH2:17][S:18][C@H:13]12)(=[O:10])[C@@H:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[OH:3]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 178476913HCID 178476913, compound

Product 1

HCID 178476914HCID 178476914, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 7β-D-mandelamido-3-(1-diethoxyphosphinylmethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid in methanol was adjusted to pH 6.5 by addition of 5% aqueous sodium methoxide then filtered. Ether was added to the filtrate and the solid material which formed was collected by filtration to give 7β-D-mandelamido-3-(1-diethoxyphosphinylmethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid sodium salt.

Workup

  1. filtrationthen filtered
  2. additionEther was added to the filtrate
  3. customthe solid material which formed
  4. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-767c96045a9f4084b7ba659193963ac4
Source dataset
uspto-grants-1978_09
Patent number
US04112086

Reaction notes

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