Phosphorus tribromide → 1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-

HRID 1763474Notes

Reaction equation

HRID 1763474 reaction equation
O[CH2:2][CH2:3][N:4]1[C:8](=[O:9])[C:7]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:6]2[C:5]1=[O:14].P(Br)(Br)[Br:16]>>[Br:16][CH2:2][CH2:3][N:4]1[C:8](=[O:9])[C:7]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:6]2[C:5]1=[O:14]

Participants

3

Reactant 2

HCID 24614Phosphorus tribromideHCID 77499N-(2-Hydroxyethyl)phthalimide

Product 1

HCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-

Procedure

A mixture of 5.35 g (0.028 mol) of N-(2-hydroxyethyl)phthalimide and 7.7 g (0.028 mol) of phosphorus tribromide is warmed until solution is obtained. The reaction mixture is then cooled and poured into ice water. The resulting solid is collected by filtration and washed with water to give N-(2-bromoethyl)phthalimide.

Workup

  1. temperatureis warmed until solution
  2. customis obtained
  3. temperatureThe reaction mixture is then cooled
  4. filtrationThe resulting solid is collected by filtration
  5. washwashed with water

Sources & evidence

ORD record
ord-61a410ae55954046b16c85c07f4c69f5
Source dataset
uspto-grants-1978_09
Patent number
US04112086

Reaction notes

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