Acetic Anhydride → HCID 135737589, compound

HRID 1763514Notes

Reaction equation

HRID 1763514 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[NH:8][C:7](=[O:12])[N:6]3[N:13]=[C:14]([CH2:16][OH:17])[CH:15]=[C:5]3[C:4]=2[CH:3]=1.[C:18](OC(=O)C)(=[O:20])[CH3:19]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[NH:8][C:7](=[O:12])[N:6]3[N:13]=[C:14]([CH2:16][O:17][C:18](=[O:20])[CH3:19])[CH:15]=[C:5]3[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 135737572HCID 135737572, compound

Product 1

HCID 135737589HCID 135737589, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2.50 g (0.01 mole) of 9-chloro-2-(hydroxymethyl)pyrazolo[1,5-c]quinazolin-5(6H)-one and 1.02 g of acetic anhydride in 50 ml pyridine are stirred for 12 hours then refluxed for 30 minutes. The reaction is evaporated; the residue is taken up in chloroform, washed with dilute aqueous sodium bicarbonate, with water and dried. The solvent is evaporated to give the title compound.

Workup

  1. temperaturethen refluxed for 30 minutes
  2. customThe reaction is evaporated
  3. washwashed with dilute aqueous sodium bicarbonate, with water
  4. customdried
  5. customThe solvent is evaporated

Sources & evidence

ORD record
ord-c0d9ddad69894f77a11e7a81d99af56a
Source dataset
uspto-grants-1978_09
Patent number
US04112096

Reaction notes

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