Potassium Hydroxide → Pirquinozol

HRID 1763523Notes

Reaction equation

HRID 1763523 reaction equation
C([O:3][C:4]([C:6]1[C:18](C)=[C:17]2[N:8]([C:9](=[O:20])[NH:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=32)[N:7]=1)=O)C.[OH-].[K+]>>[OH:3][CH2:4][C:6]1[CH:18]=[C:17]2[N:8]([C:9](=[O:20])[NH:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=32)[N:7]=1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 136463927HCID 136463927, compound

Product 1

HCID 135449340Pirquinozol

Procedure

Following the procedure of Example 25, but substituting 2-[(acetoxy)methyl]pyrazolo[1,5-c]quinazoline-5(6H)-one for 1-methylpyrazolo[1,5-c]quinazoline-5(6H)-one-2-carboxylic acid ethyl ester in Example 25 and using a mole ratio of 2 to 1 for the quantity of potassium hydroxide to ester, the title compound is obtained.

Sources & evidence

ORD record
ord-3dc5fa7de33f4c5bb634a89c50841514
Source dataset
uspto-grants-1978_09
Patent number
US04112096

Reaction notes

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