Propargyl alcohol → HCID 135737571, compound

HRID 1763525Notes

Reaction equation

HRID 1763525 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10][C:9](=[O:12])[C:8]2=[N+:13]=[N-:14].[CH2:17]([OH:20])[C:18]#[CH:19]>CCOCC>[OH:20][CH2:17][C:18]1[CH:19]=[C:8]2[N:13]([C:9](=[O:12])[NH:10][C:11]3[C:3]([C:2]([F:16])([F:15])[F:1])=[CH:4][CH:5]=[CH:6][C:7]=32)[N:14]=1

Participants

4

Reactant 2

HCID 7859Propargyl alcoholHCID 178514316HCID 178514316, compound

Product 1

HCID 135737571HCID 135737571, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

2.0 g (0.0088 mole) of 7-(trifluoromethyl)-3-diazooxindole and 10.2 g (0.176 mole or 20 equivalents) of 97% propargyl alcohol are refluxed under N2 for 4 hours, cooled, diluted with ether (200 ml) and stirred for 30 minutes. The light pink solid that forms is filtered off. Yield: 1.3 g; 52.2% crude yield.

Workup

  1. temperaturecooled
  2. filtrationThe light pink solid that forms is filtered off

Sources & evidence

ORD record
ord-177585b771224031bfb8510693444330
Source dataset
uspto-grants-1978_09
Patent number
US04112096

Reaction notes

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