4-Pyridinemethanamine → 1-(3-Fluorophenyl)-3-(pyridin-4-ylmethyl)thiourea

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	4-Pyridinemethanamine	HCID 77317	—
Edukt	3-Nitropyridine	HCID 137630	—
Edukt	(6-Methylpyridin-2-yl)methanamine	HCID 246721	—
Edukt	[4-(Trifluoromethyl)pyridin-2-yl]methanamine	HCID 3682810	—
Edukt	5-(Aminomethyl)-2-methylpyridin-3-amine	HCID 15619187	—
Edukt	4-Phenyl-2-pyridinemethanamine	HCID 19863500	—
Edukt	2-(Aminomethyl)-3-diethylaminopyridine	HCID 20310446	—
Edukt	N-(2-(Aminomethyl)pyridin-4-yl)acetamide	HCID 20310472	—
Edukt	2-(Aminomethyl)-4-methylthiopyridine	HCID 20310480	—
Edukt	2-(5-Ethylpyridin-2-YL)ethanamine	HCID 20310482	—
Edukt	2-(Aminomethyl)-3-ethylaminopyridine	HCID 20310488	—
Edukt	2-(Aminomethyl)-4-benzylpyridine	HCID 20310503	—
Edukt	(3-Chloropyridin-2-yl)methanamine	HCID 21280361	—
Edukt	(4-Methoxypyridin-2-yl)methanamine	HCID 22292761	—
Produkt	1-(3-Fluorophenyl)-3-(pyridin-4-ylmethyl)thiourea	HCID 797529	—

Reaktionsschritte

Similarly, following the above procedure but replacing the 4-aminomethylpyridine as used therein with an equal molar proportion of 2-aminomethyl-6-methylpyridine, 2-(2-aminoethyl)-5-ethylpyridine, 3-amino-5-(aminomethyl)-2-methylpyridine, 2-(aminomethyl)-3-chloropyridine, 2-(aminomethyl)-4-phenylpyridine, 2-(aminomethyl)-4-benzylpyridine, 2-(aminomethyl)-4-methoxypyridine, 2-(aminomethyl)-4-methylthiopyridine, 2-aminomethyl)-3-nitropyridine, 2-(aminomethyl)-3-ethylaminopyridine, 2-(aminomethyl)-3-diethylaminopyridine, 2-(aminomethyl)-4-acetylaminopyridine, and 2-(aminomethyl)-4-trifluoromethylpyridine, respectively, all of which may be prepared by reduction of the corresponding nitrile of formula (IVC) according to the method of Sculley, et al., supra., there is obtained

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US04112100
Quelldatensatz	uspto-grants-1978_09
ORD ID	ord-3827ead1dea846eeb89074e908757f56
Quellennotiz	uspto-grants-1978_09