Hydrazine hydrate (1:1) → HCID 20310464, compound

Participants

Reaction Steps

To a mixture of 5.76 gms. (0.02 mole) of 1-(p-nitrophenyl)-3-(4-pyridylmethyl)-2-thiourea, (Example 2, supra.), 200 ml. of ethanol and 65 ml. of hydrazine hydrate is added with stirring 0.5 grams of 5 percent palladium-on-carbon in 50 ml. of ethanol. The resulting mixture is allowed to stand overnight at room temperature and then refluxed for 2 to 3 hours. The hot reaction mixture is then filtered and the filtrate evaporated to remove solvents. The residue is 1-(p-aminophenyl)-3-(4-pyridylmethyl)-2-thiourea.

Provenance & Evidence