Acetyl chloride → HCID 20310451, compound

Participants

Reaction Steps

To a chilled (circa 0° C.) solution of 5.16 gms. (0.02 mole) of 1-(p-aminophenyl)-3-(4-pyridylmethyl)-2-thiourea (Example 19, supra.) and 75 ml. of pyridine there is added dropwise 1.48 gms. (0.02 mole) of acetyl chloride with stirring, while maintaining the temperature at circa 0° C. Upon completion of the addition, the reaction mixture is stirred for an additional 30 minutes and then allowed to stand at room temperature for about 16 hours. Solvent is then removed in vacuo and the residue suspended in water. Water is then removed to give a residue of 1-(p-acetomidophenyl)-3-(4-pyridylmethyl)-2-thiourea.

Provenance & Evidence