Acetone → HCID 20310489, compound

Participants

Reaction Steps

To 3.54 gms. (0.01 mole) of 1-(p-trifluoroacetamidophenyl)-3-(4-pyridylmethyl)-2-thiourea [prepared by reacting 1-(p-aminophenyl)-3-(4-pyridylmethyl)-2-thiourea (Example 19, supra.) with trifluoroacetic anhydride (method of Hickinbottom, Reactions of Organic Compounds, Longmans, London, 1963)] there is added 6.24 gms. (0.04 mole) of ethyl iodide in 50 ml. of dry acetone. Acetone is stripped and the residue added to 50 ml. of water. The aqueous mixture is warmed to reflux for about 30 minutes and then allowed to stand overnight. The mixture is then stripped of water to give 1-(p-ethylaminophenyl)-3-(4-pyridylmethyl)-2-thiourea.

Provenance & Evidence