HCID 22768929, compound → HCID 22768927, compound

HRID 1763572Notes

Reaction equation

HRID 1763572 reaction equation
[CH3:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-])=O)[CH:9]=2)=[N:6][N:5]2[CH:17]=[N:18][N:19]=[C:4]2[CH:3]=1>[Pt]=O.C(O)C>[NH2:14][C:10]1[CH:9]=[C:8]([C:7]2[C:2]([CH3:1])=[CH:3][C:4]3[N:5]([CH:17]=[N:18][N:19]=3)[N:6]=2)[CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 1

HCID 22768929HCID 22768929, compound

Product 1

HCID 22768927HCID 22768927, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

A mixture comprising 2.28 g of 7-methyl-6-(m-nitrophenyl)-1,2,4-triazolo[4,3-b]pyridazine (prepared as described in Example 5), 100 ml. of ethyl alcohol and a catalytic amount of platinum oxide is shaken in a Parr shaker under 40 pounds of hydrogen pressure for 11/2 hours. The reaction mixture is filtered free of catalyst and the filtrate is concentrated to afford the product of the example as a yellow solid, m.p. 182°-186° C.

Workup

  1. filtrationThe reaction mixture is filtered free of catalyst
  2. concentrationthe filtrate is concentrated
  3. customto afford the product of the example as a yellow solid, m.p. 182°-186° C.

Sources & evidence

ORD record
ord-3d4ecd9b2afe46a59cc8a6d0beec459b
Source dataset
uspto-grants-1978_09
Patent number
US04112095

Reaction notes

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