Propionylhydrazine → HCID 12726829, compound

HRID 1763584Notes

Reaction equation

HRID 1763584 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1.[C:15]([NH:19][NH2:20])(=O)[CH2:16][CH3:17]>C(O)CCC>[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[CH:6]=[CH:7][C:2]3[N:3]([C:15]([CH2:16][CH3:17])=[N:19][N:20]=3)[N:4]=2)=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 79890PropionylhydrazineHCID 122575023-Chloro-6-(4-chlorophenyl)pyridazine

Product 1

HCID 12726829HCID 12726829, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 9.0 g. of 3-chloro-6-(p-chlorophenyl)pyridazine (prepared as in Example 16), 7.4 g. of propionic acid hydrazide and 60 ml. of butyl alcohol is stirred at reflux temperature for 48 hours. The mixture is chilled, filtered and the solid is washed with petroleum ether and with water. The material is recrystallized from 50 ml. of ethyl alcohol to afford the product of the example as crystals, m.p. 197°-199° C.

Workup

  1. additionA mixture of 9.0 g
  2. temperatureat reflux temperature for 48 hours
  3. temperatureThe mixture is chilled
  4. filtrationfiltered
  5. washthe solid is washed with petroleum ether and with water
  6. customThe material is recrystallized from 50 ml
  7. customof ethyl alcohol to afford the product of the example as crystals, m.p. 197°-199° C.

Sources & evidence

ORD record
ord-176cd6b3e8224c4c8148ea4ef8fcc9e7
Source dataset
uspto-grants-1978_09
Patent number
US04112095

Reaction notes

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