Acetohydrazide → HCID 12726821, compound

HRID 1763585Notes

Reaction equation

HRID 1763585 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1.[C:15]([NH:18][NH2:19])(=O)[CH3:16]>C(O)CCC>[F:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[CH:6]=[CH:7][C:2]3[N:3]([C:15]([CH3:16])=[N:18][N:19]=3)[N:4]=2)=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 14039AcetohydrazideHCID 64224443-chloro-6-(4-fluorophenyl)pyridazine

Product 1

HCID 12726821HCID 12726821, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 6.25 g. of 3-chloro-6-(p-fluorophenyl)pyridazine (prepared as in Example 8), 4.65 g. of acetylhydrazine and 50 ml. of butyl alcohol is refluxed until a clear solution results. The reaction mixture is cooled, filtered, and the solid precipitate washed with hexane and with water. The solid is recrystallized from 50 ml. of ethyl alcohol to give the product of the example as crystals, m.p. 227°-229° C.

Workup

  1. additionA mixture of 6.25 g
  2. customresults
  3. temperatureThe reaction mixture is cooled
  4. filtrationfiltered
  5. washthe solid precipitate washed with hexane and with water
  6. customThe solid is recrystallized from 50 ml
  7. customof ethyl alcohol to give the product of the example as crystals, m.p. 227°-229° C.

Sources & evidence

ORD record
ord-104cdd1bbdde4c91a619b0036cb26cce
Source dataset
uspto-grants-1978_09
Patent number
US04112095

Reaction notes

Loading…