Acetohydrazide → 3-Methyl-6-[4-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine

Participants

Reaction Steps

A mixture of 4.50 g. of 3-chloro-6-(α,α,α-trifluoro-p-tolyl)pyridazine, 2.58 g. of acethydrazide and 100 ml. of n-butanol is heated at reflux temperature for 3 days. The solvent is removed and the resin dissolved in methylene chloride, passed through magnesol and the solid from the filtrate recrystallized from methylene chloride/hexane to afford the product as tan crystals, m.p. 199°-201° C.

Provenance & Evidence