Phosphorus oxychloride → 3-Chloro-6-(m-chlorophenyl)-4-methylpyridazine

Participants

Reaction Steps

A mixture of 25 ml. of phosphorus oxychloride and 3.0 g. of 6-(m-chlorophenyl)-4-methyl-3(2H)-pyridazinone is refluxed for 6 hrs. The mixture is concentrated to dryness under vacuum and water added to the residue. Filtration gives 3.28 g. of crystals, m.p. 138°-140° C. Recrystallized from ethanol gives 2.80 g. of crystals, m.p. 138°-141° C.

Provenance & Evidence