HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 4-Morpholineacetonitrile, alpha-(3-fluorophenyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 3-Fluorobenzaldehyde | HCID 68009 | — |
| Solvent | Methylenechloride Hexane | HCID 21226440 | — |
| Product | 4-Morpholineacetonitrile, alpha-(3-fluorophenyl)- | HCID 12449502 | — |
Reaction Steps
As in Example 35, the following reactions are carried out. m-Fluorobenzaldehyde is reacted with p-toluenesulfonic acid, morpholine and KCN to give α-(m-fluorophenyl)-4-morpholineacetonitrile as crystals (from CH2Cl2 -hexane) m.p. 74°-75° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04112095 |
| Source dataset | uspto-grants-1978_09 |
| ORD ID | ord-fe01d12b251740a79f29d3ba35903e99 |
| Source note | uspto-grants-1978_09 |