Acetohydrazide → 6-(2-Chlorophenyl)-3-methyl-1,2,4-triazolo[4,3-b]pyridazine

HRID 1763608Notes

Reaction equation

HRID 1763608 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[Cl:14])=[CH:6][CH:7]=1.[C:15]([NH:18][NH2:19])(=O)[CH3:16]>C(O)CCC>[CH3:16][C:15]1[N:3]2[N:4]=[C:5]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[Cl:14])[CH:6]=[CH:7][C:2]2=[N:19][N:18]=1

Participants

4

Reactant 2

HCID 14039AcetohydrazideHCID 124495573-Chloro-6-(2-chlorophenyl)pyridazine

Product 1

HCID 127268286-(2-Chlorophenyl)-3-methyl-1,2,4-triazolo[4,3-b]pyridazine

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

As in Example 36, a mixture of 5.5 g. of 3-chloro-6-(o-chlorophenyl) pyridazine, 3.6 g. of acetylhydrazine in 75 ml. of n-butanol is refluxed for 72 hrs. to give 2.2 g. or product as off-white crystals, m.p. 146°-148° C.

Workup

  1. additionAs in Example 36, a mixture of 5.5 g
  2. customto give 2.2 g

Sources & evidence

ORD record
ord-0af0c0b26f4148848e02630a8a2b23b7
Source dataset
uspto-grants-1978_09
Patent number
US04112095

Reaction notes

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