Butyrohydrazide → HCID 20310380, compound

HRID 1763615Notes

Reaction equation

HRID 1763615 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1.[C:18]([NH:23][NH2:24])(=O)[CH2:19][CH2:20][CH3:21]>C(O)CCC>[CH2:19]([C:18]1[N:3]2[N:4]=[C:5]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=3)[CH:6]=[CH:7][C:2]2=[N:24][N:23]=1)[CH2:20][CH3:21]

Participants

4

Reactant 2

HCID 77079ButyrohydrazideHCID 12449554Pyridazine, 3-chloro-6-[4-(trifluoromethyl)phenyl]-

Product 1

HCID 20310380HCID 20310380, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 5.0 g of 3-chloro-6-(α,α, α-trifluoro-p-tolyl)pyridazine, 3.94 g. of butyric acid hydrazide and 100 ml. of n-butanol is refluxed for 48 hr. The solvent is removed under vacuum and the residue dissolved in chloroform. The solution is passed through a column of hydrous magnesium silicate and the eluent concentrated to give 3.2 g. of product Recrystallization from CHCl3 -hexane gives crystals, m.p. 173°-175° C.

Workup

  1. customThe solvent is removed under vacuum
  2. dissolutionthe residue dissolved in chloroform
  3. concentrationthe eluent concentrated
  4. customto give 3.2 g
  5. customof product Recrystallization from CHCl3 -hexane
  6. customgives crystals, m.p. 173°-175° C.

Sources & evidence

ORD record
ord-2f49d8eb2fa94c639b285f1984cfb290
Source dataset
uspto-grants-1978_09
Patent number
US04112095

Reaction notes

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