Propionylhydrazine → HCID 12726833, compound

HRID 1763617Notes

Reaction equation

HRID 1763617 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1.[C:18]([NH:22][NH2:23])(=O)[CH2:19][CH3:20]>C(O)CCC>[CH2:19]([C:18]1[N:3]2[N:4]=[C:5]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=3)[CH:6]=[CH:7][C:2]2=[N:23][N:22]=1)[CH3:20]

Participants

4

Reactant 2

HCID 79890PropionylhydrazineHCID 12449554Pyridazine, 3-chloro-6-[4-(trifluoromethyl)phenyl]-

Product 1

HCID 12726833HCID 12726833, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

As in Example 65, 5.0 g. of 3-chloro-6-(α,α,α-trifluoro-p-tolyl)pyridazine and 3.40 g. of propionic acid hydrazide in 100 ml. of butanol is refluxed for 48 hr. to give 3.1 g of white crystals (from CHCl3 -hexane), m.p. 194°-196° C.

Sources & evidence

ORD record
ord-ac8213de90cf46a6bcabb33a4a2bfb51
Source dataset
uspto-grants-1978_09
Patent number
US04112095

Reaction notes

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