Hydrazinecarboxaldehyde → HCID 20310369, compound

Participants

Reaction Steps

A mixture of 7.0 g. of 6-[4-nitro-3-(trifluoromethyl)phenyl]-3(2H)-pyridazinone and 80 ml. of phosphorus oxychloride is heated on a steam bath for 18 hours. The solvent is removed and ice water added to the residue. Filtration gives 7.2 g. of 3-chloro-6-[4-nitro-3-(trifluoromethyl)phenyl]pyridazine as tan crystals, m.p. 129°-135° C. Recrystallization from dichloromethane-hexane gives cream colored crystals, m.p. 151°-155° C. The preceding compound is reacted with formylhydrazine in refluxing n-butanol for 24 hours to give the product of the example.

Provenance & Evidence