Ethanol → HCID 20310625, compound

Participants

Reaction Steps

A solution of 9-amino-6,11-dihydro-5H-pyrrolo[2,1-b][3]benzazepin-11-one in triethyl orthoformate (2.14 g.; 10 mmoles in 80 ml) is refluxed for 5 hours. The volatiles are removed under vacuum and the residue dissolved in 100 ml. of absolute ethanol is stirred in an ice bath as sodium borohydride (0.88 g.; 0.024 moles) is added over a period of 10 minutes. The mixture is stirred for a period of 2 hours. After concentration of the ethanol, the residue is dissolved in ethyl acetate, washed with water, dried over Na2SO4 and concentrated to dryness to yield 9-methylamino-6,11-dihydro-5H-pyrrolo[2,1-b][3]benzazepin-11-one.

Provenance & Evidence