Acetic Anhydride → HCID 20310622, compound

HRID 1763652Notes

Reaction equation

HRID 1763652 reaction equation
[NH2:1][C:2]1[CH:16]=[CH:15][C:5]2[CH:6]=[CH:7][N:8]3[CH:14]=[CH:13][CH:12]=[C:9]3[C:10](=[O:11])[C:4]=2[CH:3]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>N1C=CC=CC=1>[C:17]([NH:1][C:2]1[CH:16]=[CH:15][C:5]2[CH:6]=[CH:7][N:8]3[CH:14]=[CH:13][CH:12]=[C:9]3[C:10](=[O:11])[C:4]=2[CH:3]=1)(=[O:19])[CH3:18]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 20310593HCID 20310593, compound

Product 1

HCID 20310622HCID 20310622, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

9-Amino-11H-pyrrolo[2,1-b][3]benzazepin-11-one (2.1 g., 11.4 mmoles) dissolved in 15 ml. pyridine is treated with acetic anhydride (2 ml.) at room temperature for 19 hours. The volatiles are removed under vacuum and the residue is dissolved in chloroform, and chromatographed on silica gel. Elution with chloroform yields 9-acetamido-11H-pyrrolo[2,1-b][3]benzazepin-11-one.

Workup

  1. customThe volatiles are removed under vacuum
  2. dissolutionthe residue is dissolved in chloroform
  3. customchromatographed on silica gel
  4. washElution with chloroform

Sources & evidence

ORD record
ord-22c91394f06746bda94ab2ede59f1760
Source dataset
uspto-grants-1978_09
Patent number
US04112112

Reaction notes

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