反应详情

To 9-ethoxycarbonylamino-11-(3-dimethylaminopropylidene)-11H-pyrrolo[2,1-b][3]benzazepine (2.80 g.) in 100 ml. EtOH is added 10 ml. 2 N potassium hydroxide. Reflux is maintained for 42 hours. The volatiles are removed under vacuum and the residue is extracted with chloroform, washed with water, and dried over magnesium sulfate. Evaporation leaves a dark residue that is purified by chromatography on silica gel. Elution with 10% methanol in chloroform yields 9-amino-11-(3-dimethylaminopropylidene)-11H-pyrrolo[2,1-b][3]benzazepine.

1. temperatureReflux
2. temperatureis maintained for 42 hours
3. customThe volatiles are removed under vacuum
4. extractionthe residue is extracted with chloroform
5. washwashed with water
6. dry with materialdried over magnesium sulfate
7. customEvaporation
8. customleaves a dark residue that
9. customis purified by chromatography on silica gel
10. washElution with 10% methanol in chloroform