Ethyl 2-Formylpropionate → 4-Methyl-1-(3,4-dichlorobenzyl)-pyrazol-5-one

HRID 1763672Notes

Reaction equation

HRID 1763672 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[Cl:11])[CH2:5][NH:6][NH2:7].C([O:14][C:15](=O)[CH:16]([CH:18]=O)[CH3:17])C>C(O)C>[CH3:18][C:16]1[C:15](=[O:14])[N:6]([CH2:5][C:4]2[CH:8]=[CH:9][C:10]([Cl:11])=[C:2]([Cl:1])[CH:3]=2)[NH:7][CH:17]=1

Participants

4

Reactant 2

HCID 10898741Ethyl 2-FormylpropionateHCID 20495842(3,4-Dichlorobenzyl)hydrazine

Product 1

HCID 233344004-Methyl-1-(3,4-dichlorobenzyl)-pyrazol-5-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10.9 g of 3,4-dichlorobenzylhydrazine were added dropwise to a solution of 7.5 g of α-formylpropionic acid ethyl ester in 50 ml of ethanol. After stirring overnight at room temperature, the solvent was distilled off in vacuo and the solid residue was recrystallized from ethanol.

Workup

  1. distillationthe solvent was distilled off in vacuo
  2. customthe solid residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-968329b706574970b04a7f15185e1f81
Source dataset
uspto-grants-1978_09
Patent number
US04112227

Reaction notes

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