Ethanol → HCID 54043940, compound

Participants

Reaction Steps

A solution composed of ethyl m-[N-(4-acetoxynonyl)methanesulfonamidomethyl]cinnamate (4.1 g., 0.0088 mole), sodium hydroxide (1.05 g., 0.026 mole), water (15 ml.), and ethanol (75 ml.) is kept at room temperature 20 hours. The reaction mixture is added to water, extracted with ether, and the aqueous layer acidified. After extraction with ethyl acetate and drying overanhydrous magnesium sulfate, the ethyl acetate is removed by evaporation in vacuo. This gives, after crystallization from 1-chlorobutane, m-[N-(4-hydroxynonyl)methanesulfonamidomethyl]cinnamic acid, 2.6 g. (74% yield), m.p. 105° C. Anal. Calcd. for C20H31NO5S: C, 60.42; H, 7.86; N, 3.52 Found: C, 60.69; H, 8.43; N, 3.51

Provenance & Evidence