HCID 178465162, compound → HCID 178465164, compound

HRID 1763727Notes

Reaction equation

HRID 1763727 reaction equation
[ClH:1].[CH2:2]([NH:4][C:5](=[O:40])[C@@H:6]1[CH2:10][CH2:9][CH2:8][N:7]1[C:11](=[O:39])[C@H:12]([CH2:32][CH2:33][CH2:34][NH:35][C:36](=[NH:38])[NH2:37])[NH:13][C:14](=[O:31])[C@H:15]([CH2:27][CH:28]([CH3:30])[CH3:29])[NH:16]C(OCC1C=CC=CC=1)=O)[CH3:3]>[Pd].CO>[ClH:1].[CH2:2]([NH:4][C:5](=[O:40])[C@@H:6]1[CH2:10][CH2:9][CH2:8][N:7]1[C:11](=[O:39])[C@H:12]([CH2:32][CH2:33][CH2:34][NH:35][C:36](=[NH:37])[NH2:38])[NH:13][C:14](=[O:31])[C@H:15]([CH2:27][CH:28]([CH3:29])[CH3:30])[NH2:16])[CH3:3]

Participants

4

Reactant 1

HCID 178465162HCID 178465162, compound

Product 1

HCID 178465164HCID 178465164, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 1.8 g. of Nα -benzyloxycarbonyl-L-leucyl-L-arginyl-L-proline-N-ethylamide hydrochloride in 100 ml. of methanol is added 400 mg. of 20% palladium on carbon and the mixture is stirred under a hydrogen atmosphere for four hours. Disappearance of the starting material is determined by thin layer chromatography of samples of the solution. The catalyst is removed by filtration and the filtrate is evaporated to dryness. The product is used without further purification.

Workup

  1. customThe catalyst is removed by filtration
  2. customthe filtrate is evaporated to dryness
  3. customThe product is used without further purification

Sources & evidence

ORD record
ord-251cb6464bd54cca978aab5ce06a4422
Source dataset
uspto-grants-1978_09
Patent number
US04111923

Reaction notes

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