Dicyclohexylcarbodiimide → HCID 178465152, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of the above product g), 900 mg. of Nα -benzyloxycarbonyl-D-phenylalanine [cf. Yajima and Kubo, J. Am. Chem. Soc., 87, 2039 (1965)] and 400 mg. of 1-hydroxybenztriazole is dissolved in 40 ml. of dimethylformamide and then cooled and treated with 700 mg. of dicyclohexylcarbodiimide. The reaction is stirred at 23° C. for three days, filtered and the filtrate evaporated at 50° C. and under reduced pressure. The residue is obtained solid by repeated precipitation from methanol by ether and by ethyl acetate and ether; liquifies 130°-135° C.; [α]D23 -69° (c 1.02, methanol); ultraviolet in methanol λmax 258 E11 5.8.

Provenance & Evidence