反应详情

O-Methyl-DL-tyrosine, 114 g., is dissolved in 500 ml. of a solution of 46 g. of sodium hydroxide in water with cooling. Acetic anhydride, 80 ml., and 50% sodium hydroxide to maintain pH 9-11 are added with continued cooling. The reaction is stirred for twenty minutes at pH 11 and is then acidified to pH 1 with continued cooling. The precipitated solid is collected by filtration, washed with a small amount of water and dried to give the above named compound, mp. 144°-146° C.

1. dissolution, is dissolved in 500 ml
2. additionare added with continued cooling
3. filtrationThe precipitated solid is collected by filtration
4. washwashed with a small amount of water
5. customdried
6. customto give the