Hydrochloric Acid → O-Methyl-D-tyrosine--hydrogen chloride (1/1)

Participants

Reaction Steps

N-Acetyl-O-methyl-D-tyrosine, 24 g. is heated in 100 ml. of water and 100 ml. of concentrated hydrochloric acid for seven hours on a steam bath and let cool to room temperature overnight. The flask is swirled gently and the product crystallizes. It is separated by filtration, washed with a small amount of isopropanol, then with ether and dried to give 16.1 g. of the above named compound, [α]D23 +7.4° (c 2.02, DMF).

Provenance & Evidence