Sodium Hydroxide → HCID 20307426, compound

Temperature

100 °C

2-Bromomethyl-1,3-dioxolane (20 grams) and sec-butylamine (120 ml) were charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture was heated at a temperature of about 100° C. for a period of about 3 hours. After this time sodium hydroxide (10 grams) dissolved in water (100 ml) was added and the resulting mixture was stirred for a period of about 30 minutes. The reaction mixture was then extracted with ether and the ether solution was separated and dried over magnesium sulfate. The dried solution was filtered and stripped of solvent to yield the desired product N-sec-butyl-N-(1,3-dioxolan-2-ylmethyl)amine as an oil.

1. customequipped with a mechanical stirrer
2. temperaturethermometer and reflux condenser
3. additionwas added
4. extractionThe reaction mixture was then extracted with ether
5. customthe ether solution was separated
6. dry with materialdried over magnesium sulfate
7. filtrationThe dried solution was filtered

ORD record

ord-69fcd4da44c542859b1e90672748a1f0

Source dataset

uspto-grants-1978_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04113464