Methanethiol → HCID 70615406, compound

Participants

Reaction Steps

2,2,2-Trichloroethyl 3-bromomethyl-7β-phenoxyacetamidoceph-3-em-4-carboxylate, 1β-oxide (11.48g, 20 mmole) was reacted with methanethiol as in Example D18(i) and the resulting solution in N,N-dimethylformamide used directly in a reduction step as described in Example D18(ii) to provide the solvated title compound as a pale-yellow foam (10.90 g,), [α]D + 37.5° (c, 1.25) λmax. 269 nm (E1cm1% 165) and 276 nm. (E1cm1% 160) inflexion at 263 nm (E1cm1% 151). The P.M.R. spectrum of this product closely resembled that of the product from Example D18(ii)

Provenance & Evidence