HCID 15557208, compound → HCID 15557214, compound

HRID 1763844Notes

Reaction equation

HRID 1763844 reaction equation
Cl.[NH2:2][C:3]1[N:4]([CH3:18])[C:5]2[C:10]([C:11]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[O:19]([C:21]#N)[K]>CCCCCC>[CH3:18][N:4]1[C:3]2[NH:2][C:21](=[O:19])[C:17]3[C:12]([C:11]=2[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]1=2)=[CH:13][CH:14]=[CH:15][CH:16]=3

Participants

4

Reactant 2

HCID 15557208HCID 15557208, compoundHCID 178418250HCID 178418250, compound

Product 1

HCID 15557214HCID 15557214, compoundYield 20.1%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

The same product as in the foregoing example is prepared by heating to 270°-280° C. for 15 minutes 2.59 g (0.01 mole) of 2-amino-1-methyl-3-phenylindole hydrochloride and 3.24 g (0.04 mole) of KOCN in 25 ml of vaseline oil. The reaction mass is taken up with hexane and the insoluble parts, collected by filtration under vacuum, are washed with water in order to remove inorganic salts and crystallized from dimethylformamide, yielding 0.5 g of the pure desired product.

Workup

  1. filtrationthe insoluble parts, collected by filtration under vacuum
  2. washare washed with water in order
  3. customto remove inorganic salts
  4. customcrystallized from dimethylformamide

Sources & evidence

ORD record
ord-007c6591efcb4ce0aacd8acb1900ded4
Source dataset
uspto-grants-1978_09
Patent number
US04113731

Reaction notes

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