Sodium Acetate → HCID 70626861, compound

Participants

Reaction Steps

A solution of 9-fluoro-11β-hydroxypregna-1,4,16-triene-3,20-dione (1.0g) in a mixture of acetic acid (70 ml) and acetic anhydride (70 ml) containing p-toluenesulfonic acid hydrate (500 mg) is stirred at room temperature for 60 hours. Sodium acetate (2.0g) is added and the mixture is concentrated in vacuo. The residue is mixed with water and washed with a dilute sodium bicarbonate solution and water, dried and the residue is crystallized from ethyl acetate-hexane to afford 0.9g of the title compound, melting point 202°-203° C.

Provenance & Evidence