HCID 70625650, compound → HCID 85889757, compound

Participants

Reaction Steps

Saturated ethanolic hydrogen chloride (800 ml) was added to (7) (21 g) and the solution was refluxed for 2 hr. and left to stand at room temperature for 16 hr. Ethanol was removed under reduced pressure, the residue was taken up in methanol and sodium borohydride (30 g) added portion-wise. Methanol was removed under reduced pressure and the residue taken up in water and ether. The aqueous layer was extracted with ether and the combined ether layers extracted with dilute sulphuric acid(2N). The acid layers were basified and extracted with ether. The combined ether layers were dried (MgSO4). Removal of the solvent under reduced pressure gave the title compound as an oil.

Provenance & Evidence